Biochemistry and molecular biology
Our research programme focuses on understanding the role of proteases in both normal physiology and disease, with a particular emphasis on inflammation and cancer. Proteases tightly control key processes such as immune responses, cell-cycle progression, cell death,...
The primary role of endosomal/lysosomal system is protein degradation (Turk et al., 2012). In addition to nonspecific proteolysis in the acidic environment of endosomes/lysosomes, proteolytic enzymes cysteine cathepsins also have specific roles, such as the cleavage...