The primary role of endosomal/lysosomal system is protein degradation (Turk et al., 2012). In addition to nonspecific proteolysis in the acidic environment of endosomes/lysosomes, proteolytic enzymes cysteine cathepsins also have specific roles, such as the cleavage...
Dr. Georgy Mikhaylov
Prof. dr. Marko Fonović
Doc. dr. Livija Tušar
As part of a recently published statistical analysis of approximately 30,000 substrates of cathepsins K, V, B, L, S and F, we have developed the SAPS-ESI ("Statistical Approach to Specific Peptide Substrate-Enzyme Interaction") software platform, which contains new...