Biochemistry and molecular biology
Our research programme focuses on understanding the role of proteases in both normal physiology and disease, with a particular emphasis on inflammation and cancer. Proteases tightly control key processes such as immune responses, cell-cycle progression, cell death,...
The primary role of endosomal/lysosomal system is protein degradation (Turk et al., 2012). In addition to nonspecific proteolysis in the acidic environment of endosomes/lysosomes, proteolytic enzymes cysteine cathepsins also have specific roles, such as the cleavage...
The project What if one of the most overlooked organelles in the cell holds the key to survival under stress? Can lipid droplets decide whether a cell lives or dies? In our lab, we explore how cells reprogram their metabolism to control membrane composition under...